GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THYM | cis | rs11799420 | 1 | rs10489251 | chr1:171717534 | VAMP4 | chr1:171669298-171711214:- | 0.33 | 4.16 | 7.1E-5 | Hippocampal atrophy |
| THYM | cis | rs12780845 | 1 | rs10490958 | chr10:17233450 | CUBN | chr10:16865966-17171816:- | -0.31 | -4.71 | 8.37E-6 | Homocysteine levels |
| THYM | cis | rs9309473 | 1 | rs10496191 | chr2:73673798 | ALMS1P | chr2:73872046-73912692:+ | 0.58 | 4.72 | 8.0E-6 | Metabolite levels |
| THYM | cis | rs9309473 | 1 | rs10496193 | chr2:73773503 | ALMS1P | chr2:73872046-73912692:+ | 0.57 | 4.64 | 1.09E-5 | Metabolite levels |
| THYM | cis | rs1577917 | 1 | rs10498958 | chr6:86649705 | SNHG5 | chr6:86386726-86388451:- | 0.6 | 7.24 | 1.15E-10 | Response to antipsychotic treatment |
| THYM | cis | rs7969151 | 1 | rs10506317 | chr12:54164066 | COPZ1 | chr12:54718911-54745633:+ | -0.3 | -4.54 | 1.64E-5 | Tanning |
| THYM | cis | rs975752 | 1 | rs10509741 | chr10:101917366 | BLOC1S2 | chr10:102033713-102046439:- | -0.5 | -5.35 | 6.1E-7 | Schizophrenia |
| THYM | cis | rs9815354 | 1 | rs1052501 | chr3:41925398 | ULK4 | chr3:41288091-42003660:- | -1 | -11.02 | 1.12E-18 | Diastolic blood pressure |
| THYM | cis | rs911119 | 1 | rs1064039 | chr20:23618427 | CST9 | chr20:23583049-23586610:- | -0.48 | -4.46 | 2.25E-5 | Chronic kidney disease |
| THYM | cis | rs4660306 | 1 | rs10736426 | chr1:45984353 | CCDC163P | chr1:45960581-45965646:- | 0.8 | 13.18 | 3.67E-23 | Homocysteine levels |
| THYM | cis | rs6477998 | 1 | rs10739388 | chr9:115977175 | CDC26 | chr9:116029290-116037869:- | -0.36 | -5.71 | 1.26E-7 | Hematology traits |
| THYM | cis | rs7301826 | 1 | rs10744482 | chr12:131298195 | STX2 | chr12:131274149-131323811:- | 0.33 | 5.6 | 2.1E-7 | Plasma plasminogen activator levels |
| THYM | cis | rs703842 | 1 | rs10747783 | chr12:58176614 | FAM119B | chr12:58166383-58176323:+ | 0.41 | 5.83 | 7.7E-8 | Multiple sclerosis |
| THYM | cis | rs703842 | 1 | rs10747783 | chr12:58176614 | TSFM | chr12:58176536-58191367:+ | -0.28 | -5.16 | 1.33E-6 | Multiple sclerosis |
| THYM | cis | rs2275426 | 1 | rs10749860 | chr1:46328210 | CCDC163P | chr1:45960581-45965646:- | -0.51 | -6.14 | 1.91E-8 | Body mass index |